One of the premier peer-reviewed clinical journals in general and internal medicine, Mayo Clinic Proceedings is among the most widely read and highly cited scientific publications for physicians, with a circulation of approximately 127,000. While the Proceedings is sponsored by Mayo Clinic, it welcomes submissions from authors worldwide, publishing articles that focus on clinical medicine and support the professional and educational needs of its readers.

Continuously published since 1926, the Mayo Clinic Proceedings' content includes Nobel-prize-winning research. The Proceedings has an impact factor of 7.091, ranking it #12 out of 160 journals in the Medicine, General and Internal category, placing it among the best 8%. The Proceedings has experienced numerical increases in its Impact Factor for 17 of the past 20 years.