COMBINATORICA publishes research papers in English in a variety of areas of combinatorics and the theory of computing, with particular emphasis on general techniques and unifying principles. Typical but not exclusive topics covered by COMBINATORICA are

- Combinatorial structures (graphs, hypergraphs, matroids, designs, permutation groups).
- Combinatorial optimization.
- Combinatorial aspects of geometry and number theory.
- Algorithms in combinatorics and related fields.
- Computational complexity theory.
- Randomization and explicit construction in combinatorics and algorithms.