Circulation: Heart Failure considers for publication content related to heart failure, mechanical circulatory support and heart transplant science and medicine, including studies conducted in humans or analyses of human data, as well as preclinical studies that have direct clinical correlation or relevance. As a primarily clinical journal, few basic and preclinical studies are ultimately published. Those that will be considered are novel, and significantly and directly advance the field of heart failure. The editors are especially interested in basic science studies directly related to heart failure that are highly informative and translatable to human disease and are conducted in vertebrate models. Less than 15% of submitted articles are ultimately published. Work not directly involving heart failure or heart failure therapies will not be considered, including work on mechanisms of myocardial infarction, reperfusion injury, or arrhythmia in the absence of heart failure substrate.